Water. Tackle dehydration. Alcohol is a diuretic, which means you lose a lot of water when you drink. As a result, your liver and kidneys can’t process the alcohol properly to rid your body of toxins. Gulping gallons of water won’t cure your hangover, but it will rehydrate you and make you feel better.

Avoid coffee. While caffeine may put pep in your step, it’s also a diuretic, which will leave you even more dehydrated. Stick with water or a sports drink to restore the electrolytes you lost last night. Or try a Virgin Mary (Bloody Mary sans vodka); tomato juice is high in fructose, which helps your body metabolize alcohol faster.

Avoid acetaminophen, found in over-the-counter medications such as Tylenol. When taken with alcohol or to nurse a hangover it can cause liver damage. Ibuprofen doesn’t mix well with alcohol either. It can cause stomach irritation and bleeding, especially when you continually use it to treat hangovers or take more than the recommended dosage.

Have some healthy food. Your body works hard to restore itself back to normal after alcohol intoxication, and it needs fuel. If you don’t feel like eating, try some vegetable broth. 

Take some vitamin B6. Scientific studies also suggest that taking vitamin B6 and the amino acid cysteine assist the body in getting rid of the toxins produced by alcohol. It's important to note that you should never take more than 50mg of vitamin B6 because high doses are toxic to the nerve cells.

Get enough sleep. Alcohol can cause sleep disturbances and may be associated with decreased sleep quality and duration for some individuals. Though low to moderate amounts of alcohol may initially promote sleep, studies show that higher amounts and chronic use can ultimately disrupt sleep patterns.

Although these few science-backed ways to avoid the unpleasant symptoms that follow a night of drinking may work, there is only one best and 100% effective cure for a hangover. 

It is avoiding one by abstaining from alcohol.